MALAT1 and Familial prostate cancer: Concomitantly, a marked increase in the phosphorylation of H2AX foci was also noticed in MALAT1-silenced DU145 and PC3 cells (Fig. 3E), indicating the crucial role of MALAT1 in modulating the expression of several HR genes as well as genome integrity in both HR-proficient and -deficient prostate cancer cells.