PARP1 and Familial prostate cancer: Furthermore, genetic depletion of PARP1 in HR-proficient as well as HR-deficient prostate cancer cells suppresses the expression of DDR genes in both, shSCRM as well as shMALAT1 cells, nevertheless, the shMALAT1 cells exhibit a more notable reduction in expression, suggesting that PARP1 depletion cooperatively suppress the expression of HR genes in MALAT1-silenced cells (Supplementary Fig. S7).