MCM2 and Familial prostate cancer: Corroborating with this, the expression of genes encoding for the proteins associated with G1–S and G2–M phase transition, such as CCNA2, CCNB, CDKs, centromere proteins, and mini-chromosome maintenance (MCM2–8) was significantly decreased in MALAT1-silenced prostate cancer cells in comparison with shSCRM cells (Fig. 4C; Supplementary Fig. S4B).