Neurodegenerative diseases such as Alzheimer’s and other dementias are closely linked with tau hyperphosphorylation and postmortem findings of neurofibrillary tangles (Braak and Braak, 1991; 1995; Dutschmann et al., 2010; Braak et al., 2011; Braak and Del Tredici, 2015). Here, MAPT is linked to neurodegenerative disease.