Although increases in both pelvic and hindpaw sensitivity have been demonstrated previously in some animal urinary bladder inflammation models and may reflect overlapping dermatomes of the urinary bladder and hindpaw, not all models of urinary bladder inflammation (e.g., mice with chronic urothelial overexpression of NGF, NGF-OE) (44) exhibit both pelvic and hindpaw sensitivity. This evidence concerns the gene NGF and cystitis.