For example, Hb-DOXM@Cel, carrying doxorubicin-carrying micelles, hemoglobin crown, and celecoxib, combined with endogenous plasma contact to achieve the targeting of M2 tumor-associated macrophages (TAM), which not only alleviates the hypoxia of tumor microenvironment and kills tumor cells, but also collaborates in reprogramming M2 TAM. The gene discussed is GSTM1; the disease is neoplasm.