One recent study suggested that brain-localized CD8 T cells search for infection using generalized LWs that may increase the search efficiency, thus, may potentially minimize bystander damage to the delicate brain tissue.2 Here we rigorously analyzed data from novel experiments imaging movement ofPlasmodium-specific CD4 and CD8 T cells in brains of PbA-infected mice (Figure 1). Here, CD8A is linked to infection.