MYC and lymphoma: However, we also observed a less severe impact of CJL on circadian gene expression in spleens of healthy mice than in their livers, using samples collected at four-hour intervals across the circadian cycle for each tissue.11 The influence of circadian disruption in spleens of Eμ-MYC mice may be further subdued by the aggressiveness20 or the intrinsic heterogeneity47,48 of Eμ-MYC lymphoma.