In Eμ-MYC mice, humanc-MYC is expressed at a high level in B cells via transgenic expression under the control of the IgH enhancer resulting in generation of MYC-driven lymphomas.19 The spleen is the site of B cell maturation and we have previously shown that deletion of the clock componentCry2 leads to enhanced expression of MYC in the spleen of Eμ-MYC mice.21 Thus, we assessed the impact of circadian disruption in the spleen tissues of the Eμ-MYC mice. Here, CLOCK is linked to lymphoma.