We use a disruptive lighting schedule, chronic jetlag (CJL), that we previously demonstrated disrupts rhythmic expression ofCry2 mRNA in peripheral tissues of C57BL/6J mice.11 We expected that CJL would alter CRY2-dependent modulation of c-MYC and could thereby enhance tumor development and decrease overall survival in Eμ-MYC mice. Here, MYC is linked to neoplasm.