MYC and neoplasm: This study specifically assessed the impact of CJL on the Eμ-MYC mouse model of lymphoma, based on previous reports demonstrating that CRY2 facilitates the turnover of c-MYC and that homozygous deletion ofCry2 in Eμ-MYC mice enhances tumorigenesis.21 Here, we investigated the impact of environmental circadian disruption on c-MYC accumulation and tumor burden in Eμ-MYC mice.