These two non-classical variants in GJB2 have already been described as causative of non-syndromic hearing loss, ichthyosis and in some cases keratoderma on the palms and soles (Pang et al., 2014; Shen et al., 2019) which are consistent with the observed phenotype. The gene discussed is GJB2; the disease is Palmoplantar keratoderma.