Besides the aforementioned families diagnosed with non-syndromic SNHL, five patients in this study (3%) were diagnosed with syndromic hearing loss, being MITF and PAX3 pathogenic or likely pathogenic variants responsible of 4 cases of Waardenburg syndrome (#P33, #P34, #P35 and #P49 in Table 2). The gene discussed is PAX3; the disease is hearing loss disorder.