While the individual members of the strong up-regulated signature we identified, IFN-γ, IP-10/CXCL10, and IL-9, have been linked to AD previously [5, 9, 36, 60, 102], with the possible exception of IP-10/CXCL10 they have not been appreciated as playing a strong role in AD progression. This evidence concerns the gene CXCL10 and Alzheimer disease.