Moreover, after excluding cases who had died within 6 months of the first measurement of serum tumor markers after surgery, elevated postoperative serum SCC and CEA still predicted poor overall survival (SCC HRadjusted: 2.56, 95% CI: 1.60-4.10, CEA HRadjusted: 2.74, 95% CI: 1.34-5.63). This evidence concerns the gene CEACAM5 and neoplasm.