HIF1A and Familial prostate cancer: Chrysin, also known as 5,7-dihydroxyflavone, is another natural compound with anti-tumor properties, chrysin inhibits the growth and VM formation of prostate cancer cell line PC-3 by inhibiting HIF-1α, SPHK-1, and phosphorylation of the AKT/GSK-3β signaling pathway (62).