BCL2L11, also known as BIM (Bcl-2 interacting mediator of cell death), a Bcl-2 homology 3 (BH3)-only proapoptotic protein that belongs to the Bcl-2 family, is epigenetically silenced via the combinatorial deregulation of DNA methylation and histone acetylation in ALK+ ALCL (66, 71). This evidence concerns the gene BCL2L11 and anaplastic large cell lymphoma.