However, other T-cell lymphoma cells exposed to the same treatment exhibited expression of genes characteristic of ALCL (ID2, LGALS4, c-JUN) as well as loss of T-cell phenotype marked by loss of CD3, LCK, and ZAP70 expression indicating that global DNA demethylation and histone acetylation are critical for cellular reprogramming towards an ALCL-like phenotype (66). This evidence concerns the gene ZAP70 and anaplastic large cell lymphoma.