ALK and anaplastic large cell lymphoma: It has been reported that NPM::ALK downregulates SHP1 tyrosine phosphatase, a negative modulator of multiple cytokine signaling pathways, including Epo-R, IL-4, IL-13, IL-3R, IL-2R, through STAT3-mediated upregulation of DNA methyltransferase 1 in ALK+ ALCL (102, 123, 124).