STK11 and neoplasm: It was found that women with LKB1-deficient EC had elevated levels of the pro-TAMs recruitment chemokine CCL-2 in peripheral blood serum, suggesting that CCL-2 produced by the tumor-bearing uterus can enter the circulation and that serum CCL-2 may be used as a potential circulating biomarker to monitor tumor progression or predict progression risk, but this is still at an early stage and not supported by relevant data (23).