CSF1R and cancer: Moreover, by finding that macrophages in the population possessing the immunoglobulin-like structural domain 4 of CSF-1R within the amino acid change from histidine to arginine, the CSF1Rc.1085A>G gene variant, exhibited resistance to CSF-1 stimulation and were more susceptible to CSF-1R inhibitors in terms of receptor phosphorylation and endocytosis, suggesting that our CSF- 1Rc.1085A>G gene variant could be used as a potential predictive biomarker for predicting the efficacy of targeting CSF-1R signaling for cancer therapy (35).