p62 increased the levels and activities of Nrf2 by suppressing Keap1-mediated proteasomal degradation in PCa cells and tissues, and high levels of p62 promoted growth of PCa through accelerating the Keap1/Nrf2/ARE system and by activating Nrf2 pathway, p62 stimulates the transcription of Nrf2’s target genes, inhibits ROS in PCa cells, which promotes PCa cell proliferation, anti-apoptosis and invasion. The gene discussed is SQSTM1; the disease is posterior cortical atrophy.