During pancreatic carcinogenesis, Nrf2 exerts tumor suppressive effects by binding to ARE and activating its downstream target genes (NQO1, SOD1, HO-1, ATF3, IL-17D, and SQSTM1/p62) that regulate cellular antioxidant/detoxification responses, immune surveillance and autophagy (63). This evidence concerns the gene SQSTM1 and neoplasm.