KEAP1 and hepatocellular carcinoma: The targeted regulation of Nrf2 can be used to treat a variety of chronic diseases, including HCC (58).Raspberry extract is reported to significantly reduce ROS levels in H2O2-induced oxidatively damaged HCC HepG2 cells, increases GSH content and CAT activity, and activates the expression of the proteins Keap1, Nrf2, HO-1, NQO1, and γ-GCS through the Keap1/Nrf2 pathway (59).