Of the 25 AAbs observed to be increased in the serum of OSCC samples (Figures 2A–O), a subset of candidate antigens have been described as overexpressed in the context of oral cancer, including GGPS1 (32), KRAS (33), MAP2K6 (34), PRDX1 (35), PSME3 (36), S100A9 (37), and TAGLN (38). Here, TAGLN is linked to lip and oral cavity carcinoma.