Gene function enrichment analyses showed that “pathologic M”-related ASEs in KIRC mainly enriched to “Signaling by Rho GTPases” pathway, “neoplasm histologic grade”-related ASEs in BLCA mainly enriched to “mRNA metabolic process”, “CALGB cytogenetics risk category”-related ASEs in LAML mainly enriched to “Signaling by Receptor Tyrosine Kinases”. The gene discussed is NTRK1; the disease is bladder transitional cell carcinoma.