CD40 and neoplasm: There is good evidence that CD40 expression by tumor endothelium is engaged by CD40L+ T cells that secrete IFNγ and TNFα, leading to expression of adhesion molecules, like intracellular adhesion molecule-1 (ICAM-1), E-selectin (CD62E) and vascular cell adhesion molecule-1 (VCAM-1), which are required for trafficking and trans-endothelial migration (121).