TNF and amyotrophic lateral sclerosis: Furthermore, we found that GAx, GCoco and GAx + coco induced a decrease in the fat mass percentage compared to GControl (Figure 2), which could be considered a protective factor for ALS since a decrease in body fat is related to a decrease in proinflammatory cytokines, i.e., IL-6 or TNF-α, both involved in the pathogenic mechanism of inflammation that underlies the disease (51).