The following risk factors may increase the risk of kidney stones: smoking initiation, watching TV (sedentary behavior), urinary sodium, the urinary sodium/potassium ratio, the urinary sodium/creatinine ratio, serum calcium, 25OHD, eGFRcrea, eGFRcys, BMI, waist circumference, T2DM, fasting insulin, glycated hemoglobin, and hypertension. The gene discussed is INS; the disease is nephrolithiasis.