Second, we used the latest and most extensive kidney stones GWAS and genetically found quite a few new risk factors associated with kidney stones, such as smoking initiation, sedentary behavior, urinary sodium, the urinary sodium/potassium ratio, the urinary sodium/creatinine ratio, waist circumference, fasting insulin, glycated hemoglobin, and hypertension. The gene discussed is INS; the disease is Hypertension.