Resveratrol, carnosic acid, beta carotene, and curcumin can activate autophagy through the SIRT1/FOXO1/Rab7 axis (167), PI3K/Akt/mTOR (168), activate AMPK and JNK1, phosphorylated Bcl-2 and Bim and subsequently disrupted their interactions with Beclin1 to treat diabetic cardiomyopathy (169). The gene discussed is AKT1; the disease is diabetic cardiomyopathy.