After adjusting for baseline age, waist circumference, body weight, fatty liver, BMI, alcohol consumption, exercise habits, smoking status, diastolic blood pressure, systolic blood pressure, total cholesterol, AST, ALT, and GGT when TG/HDL-C ratio was less than 1.188, the risk of incident T2DM in Japanese men decreased by nearly 89.5% for each unit increase in TG/HDL-C ratio (HR = 0.105, 95% CI = 0.025, 0.451; P = 0.002). This evidence concerns the gene GPT and type 2 diabetes mellitus.