After adjusting for confounding factors such as baseline age, fatty liver, BMI, waist circumference, ALT, AST, body weight, exercise habits, GGT, total cholesterol, HbA1c, alcohol consumption, smoking status, fasting plasma glucose, systolic blood pressure, and diastolic blood pressure, for each unit increase in baseline TG/HDL-C below the threshold, the risk of developing incident T2DM in Japanese men was decreased by nearly 89.5%. The gene discussed is GPT; the disease is type 2 diabetes mellitus.