Non-surgery comparator-subjects-with-obesity versus normal weight group: higher adipsin (29% difference), higher FGF23 (40% difference), higher ANGPTL4 (30% difference) and lower (17% difference) were seen; adiponectin, ANGPTL3, FGF19, FGF21 and myonectin did not differ. The gene discussed is ANGPTL4; the disease is obesity due to melanocortin 4 receptor deficiency.