Despite the marked weight loss following surgery, hepatokine, adipokine and myokine parameters did not differ to the non-surgery comparator-subjects-with-obesity apart from adiponectin that increased significantly after surgery; this result suggests that adiponectin is more sensitive to weight changes, and that weight loss, but not necessarily to the level of a BMI less than 34 kg/m2, may reset the homeostatic set point of adiponectin. This evidence concerns the gene ADIPOQ and Obesity.