The hepatokine ANGPTL3 did not differ between surgery and comparator-subjects-with-obesity or normal-weight subjects; ANGPTL3 levels have been shown to differ post bariatric surgery depending on the type of surgery undertaken though, in accord with the results here, they were reported not to change following Roux-en-Y surgery (31), suggesting that differing bariatric surgery procedures have differing metabolic impacts. Here, ANGPTL3 is linked to obesity due to melanocortin 4 receptor deficiency.