On the other hand, atherosclerosis plaques are rich in foam cells that secrete various pro-inflammatory factors such as IL-1, IL-2, and tumor necrosis factor, which further aggravate the inflammatory response at the lesion and rupture the plaque (Baker, Hayden & Ghosh, 2011; Bobryshev et al., 2016; Peng et al., 2020; Zhong et al., 2020). This evidence concerns the gene TNF and atherosclerosis.