Importantly, SMI showed significantly independent correlation with the adverse outcomes in patients with PLA (odds ratio (OR) 0.787, 95% CI [0.649–0.954], P = 0.015) after adjusting for confounding factors (age, gender, ALT, total bilirubin; PT, albumin, CRP, creatinine, pleural effusion) in multivariable analysis (Table 4). The gene discussed is F2; the disease is Pleural effusion.