LYRM4 and central nervous system cancer: Furthermore, variables with P < 0.1 in the univariate Cox regression analysis including WHO grade, EGFR status, age, 1p/19q codeletion, IDH status and LYRM4-AS1 were included into multivariate Cox regression analysis, the result indicated that WHO grade (HR: 0.491; CI [0.314–0.766]; P = 0.002), age (HR: 0.517; CI [0.387–0.698]; P < 0.001), IDH status (HR: 5.009; CI [3.312–7.576]; P < 0.001) and LYRM4-AS1 (HR: 1.836; CI [1.278–2.639]; P = 0.001) could serve as independent factors for predicting OS of patients with glioma.