There are relatively few studies on the mechanism of role of LYRM4-AS1, and a recent report found that the beneficial effects of the bone marrow mesenchymal stem cell-derived exosomes on the pathogenesis of osteoarthritis through targeting the LYRM4-AS1/GRPR/miR-6515-5p signaling pathway. This evidence concerns the gene LYRM4 and osteoarthritis.