In the early stages of sepsis, NETs appearto have a protective function, but as the disease progresses, an enhancedNET release may contribute to thrombosis and multiorgan dysfunction.112 During infectious shock, miR-15b-5p and miR-378a-3pcan advance the formation of NETs and aggravate lung injury by targetingneutrophil polycystin 1 (PKD1) and activating the AKT/mTOR autophagypathway. Here, PKD1 is linked to Sepsis.