Moreover, we examined whether the PAI-1/BDNF ratio correlateswith disease severity, as measured by Mini-Mental State Examination.Our results showed that BDNF serum levels are lower (13.7% less) andPAI-1 levels are higher in Alzheimer patients with dementia than inAlzheimer patients with amnestic mild cognitive impairment patients(23% more) or controls (36% more). Here, BDNF is linked to dementia.