PAI-1 serum levelsare increased in Alzheimer patients with dementia and amnestic mildcognitive impairment as compared to controls, a result in line withseveral previous observations in Alzheimer animal models and humans.26-30 As a consequence, tPA/plasmin synthesis in Alzheimer could be reduced,favoring the accumulation of β-amyloid and Alzheimer development.24 The gene discussed is PLG; the disease is dementia.