BDNF and Cognitive impairment: Another possible implication of our findingsis to use the PAI-1/BDNFratio as a selective marker of Alzheimer dementia able to distinguishfrom other prodromal Alzheimer stages and/or cognitively healthy subjects.Interestingly, this increase in the PAI-1/BDNF ratio is selectivelypresent in Alzheimer patients with full dementia and not in amnesticmild cognitive impairment and controls.