SERPINE1 and Cognitive impairment: Post hoc analysis showedthat the PAI-1/BDNF ratio was significantly higher in the Alzheimergroup as compared to amnestic mild cognitive impairment (36.4% more)(p < 0.0001; 95% CI: −0.2, 0.097) and controls(40% more) (p < 0.0001; 95% CI: −0.25,−0.082) (Figure 2).