In addition to RUNX1-EVI1 fusions, several cases of a t(3;12)(q26;p13) translocation have been reported in poor prognosis AML, MDS, and blast crisis MDS.74 This translocation leads to a fusion of ETV6 to the MECOM locus (Figure 3A, right panel). The gene discussed is RUNX1; the disease is acute myeloid leukemia.