MECOM and acute myeloid leukemia: EVI1 and RUNX1 levels also seem to positively correlate in AML patient samples, indicating a causal relationship which appears to relate to RUNX1 exerting a regulatory role on EVI1 expression via mediating acetylation of histone H3 in the EVI1 promoter region.98 Whether translocations involving the RUNX1 gene influence its ability to bind to the EVI1 promoter has yet to be determined.