We have previously discussed how the epigenetic state of the EVI1 locus and corresponding transcript levels can be preserved after the malignant transformation of HSCs with the MLL-AF9 oncogenic fusion gene.68 In an MLL-AF9 AML mouse model, the GMP-derived EVI1low murine leukemic cells showed a higher degree of apoptotic priming and were more sensitive to treatment with doxorubicin and to treatment with the LSD1 inhibitors IMG-7289 and IMG-98 than the HSC/multipotent-progenitor (MPP)-derived EVI1high malignant cells. This evidence concerns the gene MECOM and acute myeloid leukemia.