Amplification of the EVI1 locus at 3q, for example spanning the region of 3q26q29, is a frequent early event in myeloid malignancies that occur in Fanconi anemia (FA) patients,94,95 with the EVI1 locus being contained in the minimally amplified region (Figure 3C). The gene discussed is MECOM; the disease is Fanconi anemia.