In AML with t(3;8)(q26;q24), an MYC “super-enhancer” comprised of several enhancer modules is translocated to the MECOM locus (Figure 3B, right panel).83 One of these modules serves as a binding site for key transcription factors of early hematopoiesis, including ERG, FLI1, GATA2, LMO2, LYL1, and RUNX1.83,84 This enhancer module facilitates the interaction of the enhancer with the EVI1 promoter via promoter-enhancer looping, and is essential for the overexpression of EVI1. The gene discussed is LMO2; the disease is acute myeloid leukemia.