Qin et al. [8] studied the relationship between serum BNP and endothelin-1 (ET-1) levels and left atrial pump function in HF patients and found that BNP and ET-1 were negatively correlated with the left atrial ejection fraction, left atrial passive emptying fraction, and left atrial active emptying fraction (p < 0.05). The gene discussed is EDN1; the disease is hydrops fetalis.