FMR1 and fragile X syndrome: A significant difference in total FMRP between control and FXS HDFs was detected, with FXS- lines exhibiting a lower total amount of FMRP compared to control lines prior to reprogramming, [t(7.00) = 5.248, p ≤ 0.001; Figure 3C], and following reprogramming [t(4.00) = 3.091, p = 0.030; Figure 3C’].