DLG4 and neurodevelopmental disorder: Expression of the scaffolding protein PSD-95, for example, modifies glutamate transmission through alterations in NMDA and AMPA-receptor recruitment, stability, and function in the postsynaptic compartment (El-Husseini et al., 2000; Ehrlich and Malinow, 2004; Chen et al., 2015), and is associated with cognitive phenotypes in a range of neurodevelopmental disorders (Tsai et al., 2012; Lelieveld et al., 2016).