This was also recapitulated when we looked at FGF-21 and CCL25 which were significantly increased, while LIF-R and 4E-BP1 were nominally significant in HU gout: we observed significantly higher concentrations of these proteins in HU gout compared to NU or NU gout, but no difference was observed in HU gout compared to AH, nor in NU gout compared to normouricemia (Figure 2E). The gene discussed is FGF21; the disease is gout.