,62 Osteoimmunological reports support a suppressive role of TRAIL in RANKL and M-CSF-induced osteoclast differentiation,63,64 with others showing the capacity of recombinant TRAIL to inhibit osteoclastogenesis and bone resorption via inhibition of RANKL signaling in a mouse model of collagen-induced arthritis.62 The gene discussed is TNFSF10; the disease is arthritic joint disease.