Six significantly distinct proteins were identified in the serum proteomic profile of gout flares, these patients having elevated circulating concentrations of MMP-1, IL-6, VEGFA, and CCL23 and decreased DNER (Delta and Notch-like epidermal growth factor-related receptor) and CD6 levels (Figures 4B and S2A). The gene discussed is MMP1; the disease is gout.