HGF and peripheral arterial disease: Patients with low HGF had an increased incidence of 3-year MALE (34% vs 12%, p = 0.001), major amputation (7% vs 2%, p = 0.023), vascular intervention (32% vs 12%, p = 0.001), and worsening PAD status (19% vs 9%, p = 0.006) compared to patients with high HGF (Table 4).