To assess whether the upregulation of stem cell transcription factors participate in integrin αvβ3/PI3K/AKT-induced tumor cell proliferation, we measured the gene expression levels of SOX2, Oct3/4, c-Myc, Tert, KLF4 and Nanog in PBS- or FN-treated A549 and Lewis cells by real-time PCR. The gene discussed is FN1; the disease is neoplasm.