We suspect that the upregulation of NPHS1 expression could be facilitated by a G4 ligand, given that the G4 sequence is formed in the non-template strand of the NPHS1 gene [46].Similarly, most of the other mutations in the selected genes affected the RNA G4 stability in their context suggesting that G4s influence the translation or splicing efficiency of glomerular genes in NS patients. This evidence concerns the gene NPHS1 and Netherton syndrome.