In addition, other factors affect the life of a breast cancer patient, such as the infiltration of lymphocytes, especially for patients who have the disease before the age of forty, as the presence of a large number of CD8+ T lymphocytes contributes to the high survival rates of the patient, and this shows It is more clearly in patients who have ER-negative compared with patients with ER-positive [43]. The gene discussed is ESR1; the disease is breast carcinoma.