TNF and polycystic ovary syndrome: Likewise, Amiri Siavashani et al. showed that the Chromium supplementation (200 μg/day) could lead to decrease in hs-CRP level as well as IL-1 downregulation without change in the expression level of IL-8 and TNF-α in women with polycystic ovary syndrome (PCOS) after 8 weeks intervention [86].