In conclusion, SARS-CoV-2 viremia was associated with variants of rs2071746 (HMOX1) rs78958998 (SERPING1), rs713400 (TMPRSS2), rs11052877 (CD69), rs33980500 (TRAF3IP2), rs2660 (OAS1) and rs896 (VIPR1), after adjusting by age and sex, COVID-19 severity and treatment with ACE inhibitors and Angiotensin II blockers. This evidence concerns the gene SERPING1 and COVID-19.