HCC vs. chronic hepatitis: hnRNPH1 alone: 85.2%/76.5%, AUC 0.87; AFP alone: 69.3%/87.9%, AUC 0.79; hnRNPH1 + AFP: AUC 0.89 (p < 0.05 vs. AFP); HCC vs. cirrhosis: hnRNPH1 alone: 86.4%/54.0%, AUC 0.65; AFP alone: 46.6%/88.3%, AUC 0.67 hnRNPH1 + AFP: AUC 0.75 (p < 0.05 vs. AFP). The gene discussed is HNRNPH1; the disease is hepatocellular carcinoma.