Combined score (H19-204 + LncRNA THEMIS2-211+ PRKACA-202) had AUC, Se, Sp for HCC in the validation set: 0.88, 70.9, 94.6%; LncRNA THEMIS2-211 for aerly stage HCC had AUC, Se, Sp of 0.81, 82.8, 70.8% The gene discussed is PRKACA; the disease is hepatocellular carcinoma.