Inflammatory cytokines (IL-1β, TNF-α, IL-6, and IL-8) produce nitric oxide, superoxide, peroxynitrites, and hydroxyl radicals, altering the DNA structure and leading toward neoplasm. Cellular proliferation occurs with the upregulation of β-catenin, c-myc, and cyclin D. The gene discussed is MYC; the disease is neoplasm.