Th subsets: Early studies showed that TT patients had a Th1 subset, while Th2 was predominant in LL patients and was also constant with the T-cell and B-cell responses seen in lepromatous and TT, respectively, but other studies illustrated that a few leprosy patients also showed Th profile with both IFN-γ (TH1) and IL-4 (TH2) [91]. This evidence concerns the gene IFNG and leprosy.