proposed the following diagnostic criteria for CAPS in children and adults: elevated inflammatory markers (CRP and SAA) plus ≥2 of 6 typical CAPS signs or symptoms, which include (1) an urticaria-like rash, (2) cold/stress triggered episodes, (3) sensorineural hearing loss, (4) musculoskeletal symptoms (arthralgia/arthritis/myalgia), (5) chronic aseptic meningitis, and (6) skeletal abnormalities (epiphyseal overgrowth/frontal bossing) (16). The gene discussed is CRP; the disease is cryopyrin-associated periodic syndrome.