Genes classified as hallmark signatures of cancer (35), such as those related to glycolysis, hypoxia-induced autophagy, stress response, fatty acid binding and lipid droplet accumulation, amino acid transport and metabolism, angiogenesis, and proinflammatory cytokines such as Il1a, Il1b, C3, and Cxcl1, were upregulated in RDEB samples across all cell types (Figure 1D). Here, C3 is linked to cancer.