Specifically, increased ADAM19 (OR = 0.99; 95% CI, 0.98–0.99; P = 5.40 × 10−7) decreased the risk of asthma, whereas elevated IL1R1 (OR = 1.03; 95% CI, 1.02–1.04; P = 1.32 × 10−11), ECM1 in plasma (OR = 1.00; 95% CI, 1.00–1.01; P = 1.83 × 10−6), ECM1 in the brain (OR = 1.05; 95% CI, 1.03–1.08; P = 9.37 × 10−6), and PDLIM4 (OR = 1.05; 95% CI, 1.04–1.07; P = 3.55 × 10−14) increased the risk of asthma. The gene discussed is ECM1; the disease is asthma.