OCLN and inborn error of immunity: As shown in Figures 5D, E, GSEA enrichment analysis indicated that the drug metabolism cytochrome P450, epithelial cell signaling in helicobacter pylori infection and metabolism of xenobiotics by cytochrome P450 were upregulated in the low OCLN expression group, and the DEGs were significantly enriched in KEGG pathways such as IL-17 signaling pathway, Tight junction and primary immunodeficiency.