Furthermore, KEGG enrichment analysis demonstrated that CDH5 and its co-expressed mRNA were enriched to some signaling pathways such as cytokine-cytokine receptor interaction-related signaling pathway, JAK-STAT signaling pathway, chemokine signaling pathway, IL2-STAT5 signaling pathway that have been reported to be associated to tumor immunity (34–38). This evidence concerns the gene IL2 and neoplasm.