The ESTIMATE algorithm was used to calculate the immune scores in pan-cancer, and the results showed that CDH5 was positively correlated with the immune scores of 13 tumors including ACC, BLCA, COAD, ESCA, HNSC, KICH, LUSC, PAAD, PCPG, PRAD, READ, SKCM, and STAD but CDH5 was negatively correlated with immune score of THCA (Figure 6). This evidence concerns the gene CDH5 and cancer.