Hallmarks-GSEA results demonstrated that CDH5 was significantly associated with immune regulative pathways such as complement, IL2-STAT5 signaling, inflammatory response, interferon gamma response, TNFA signaling via NFkB, IL6-JAK-STAT3 signaling, and interferon alpha response in 20 tumors including BLCA (Figure 5). The gene discussed is TNF; the disease is bladder transitional cell carcinoma.