Therefore, CD47, which is highly expressed in AML cells and hinders phagocytosis via interacting with SIRP1α on target cells (189, 190), can be neutralized by using a monoclonal antibody and the synergistic impact of TRAIL and anti-CD47 antibody on macrophage phagocytosis of tumor cells can be investigated for further studies. The gene discussed is CD47; the disease is acute myeloid leukemia.