Although these chemokines are induced by M2a stimulants, the upregulation of their expression by inflammatory agents such as LPS (175), their association with the progression of autoimmune diseases such as arthritis (176, 177), and their role in attracting the anti-tumorigenic Th17 cells (173, 174, 178, 179) suggest that TRAIL may enhance inflammatory response in M2a macrophages by increasing the expression of these chemokines. The gene discussed is TNFSF10; the disease is Arthritis.