Iguratimod can also interfere with the translocation of NF-κB from the cytoplasm to the nucleus induced by TNF-α, and inhibit the production of TNF-α, IL-6, IL-8, monocyte chemoattractant protein and colony stimulating factor by RA-FLS stimulated by TNF-α or LPS (56). Here, TNF is linked to rheumatoid arthritis.