In addition, we detected the expression of five known apoptosis-related factors in transplanted tumor and found that the expression intensity of pro-apoptotic factors (Caspa-se-3, Caspase-8, Fas) in RBE+M2 group was lower than that in RBE group, while the expression of anti-apoptotic factor Bcl-2 was stronger than that in RBE group. Here, CASP8 is linked to neoplasm.