In stratified analysis by CNS and non-CNS lymphoma type, we determined significant associations between EVs bearing PD-L1 (OR = 1.94; 95% CI: 1.01 – 3.72, p = 0.046), CD40 (OR = 2.66; 95% CI: 1.12 – 6.35; p = 0.027), TNF-RII (OR = 9.64; 95% CI: 2.52 – 36.86; p = 0.001) and/or IL-6Rα (OR = 8.34; 95% CI: 1.73 – 40.15; p = 0.008) and non-CNS lymphoma (Table 4). Here, TNF is linked to primary central nervous system lymphoma.