Although, RA microenvironment is primarily constituted by an array of immune cells, the disease pathology is precipitated by CD4+ T cells and more specifically, is Th17-driven where it has been shown that most of the Th17 secreted cytokines, including IL-17, IL-22, TNF-α, IFN-γ are inflammatory in nature (2, 5, 6). This evidence concerns the gene CD4 and rheumatoid arthritis.