In that study, keloid exhibited marked increases in the interaction between transforming growth factor-β (TGFβ) and its receptor as well as the interaction between POSTN and integrin alpha-V (ITGAV)/ITGB5 compared to normal scars, suggesting that the TGFβ pathway and POSTN may actively participate in the initiation and progression of keloid. The gene discussed is ITGB5; the disease is keloid.